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What is homocysteine?

Homocysteine is a naturally produced, sulfur-containing amino acid that is metabolized to create other essential compounds such as methionine and cysteine. High homocysteine levels are associated with elevated cardiovascular risk including coronary artery disease, heart attacks, blood clots, or strokes, and neurological disorders such as dementia.

Why is homocysteine important?

Homocysteine can elevate cardiovascular risk through a mechanism that activates monocytes, a type of immune cell that promotes an inflammatory response. Thus, higher homocysteine levels are linked to increased inflammation. SiPhox Health includes homocysteine in our foundation panel to help monitor and manage homocysteine levels.

How can I better understand my results?

To assist in interpreting results, the American Heart Association outlined ranges that indicate normal levels of fasting plasma homocysteine in addition to moderate, intermediate, and severe hyperhomocysteinemia.

Ranges specific to the Cardiometabolic Program:

  • Optimal: <4 umol/L
  • Good: 4-5.9 umol/L
  • Fair: 6-9.9 umol/L
  • Pay attention: 10-14.9 umol/L
  • Alert: >15 umol/L

High levels of homocysteine may be caused by low levels of B vitamins and/or folate, aging, excessive alcohol use, smoking, thyroid or kidney diseases, medications, or genetic diseases. It is important to consult with your physician if you are concerned about any of your results.

How can I maintain optimal homocysteine levels?

If you have elevated homocysteine levels, you can try:

Lifestyle changes: Reducing stress, cutting back on coffee, limiting alcohol intake, quitting smoking, and regularly engaging in resistance training can help to mediate elevated homocysteine levels.

Supplementation: Supplementing with B vitamins (B6, B12, folic acid) can aid in decreasing higher homocysteine levels.

Where can I learn more?

DISCLAIMER: IF YOU ARE CONCERNED WITH ANY OF YOUR RESULTS, PLEASE CONSULT WITH YOUR PHYSICIAN.