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What is ApoA1?

ApoA1 (apolipoprotein A) is a protein carrier for HDL-C. ApoA1 is considered the most informative biomarker for “good” cholesterol and can be used to determine your risk for cardiovascular disease. ApoA1 in particular is the most abundant protein associated with HDL-C.

Note: HDL-C is known as “good” cholesterol because of its anti-atherogenic effects (prevents plaque from clogging arteries), but high HDL-C can result in negative cardiovascular outcomes as well.

Why is ApoA1 important?

Both HDL cholesterol and ApoA1 are, in most clinical conditions, anti-atherogenic, so the higher the values, the lower the cardiovascular risk. Your ApoA1 measurement can be an important predictor of cardiovascular health and is thus included in SiPhox Health’s foundation panel.

How can I better understand my ApoA1 results?

To better understand your ApoA1 results, you can use the following ranges:

Males:

  • Out of range: 0-100 mg/dL
  • In range: 100-115 mg/dL
  • Optimal: 115-200 mg/dL
  • In range: 200+ mg/dL

Females:

  • Out of range: 0-100 mg/dL
  • In range: 100-125 mg/dL
  • Optimal: 125-200 mg/dL
  • In range: 200+ mg/dL

High ApoA1 may be caused by genetic disorders, certain medications, or recent weight loss. Low ApoA1 may be caused by diabetes, coronary artery disease, Tangier disease (< 25 mg/dL) [1], liver disorders, and certain lifestyle choices such as smoking cigarettes. Because ApoA1 levels can be an indicator of many deleterious diseases, it is important to consult with your physician if you are concerned with your levels. Aim for levels to fall higher in the normal range.

How can I maintain optimal ApoA1 levels?

If you need to maintain or adjust your ApoA1 levels, consider the following strategies[2]:

Dietary Changes: Limiting foods with added sugar (sweets, jam, sugar-sweetened beverages) and consuming fermented dairy products (fermented milk, cheese) can help to regulate ApoA1 levels.

Lifestyle Changes: To raise ApoA1 levels, try avoiding smoking and increasing physical activity. If you are obese, consider losing weight through a healthy diet and exercise.

Where can I learn more?

DISCLAIMER: IF YOU ARE CONCERNED WITH ANY OF YOUR RESULTS, PLEASE CONSULT WITH YOUR PHYSICIAN.

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